Modeling studies on the role of vitamins B1 (thiamin), B3 (nicotinamide), B6 (pyridoxamine), and caffeine as potential leads for the drug design against COVID-19Article Published on 2022-11-072022-11-15 Journal: Journal of molecular modeling [Category] SARS, 신약개발, 치료제, [키워드] ACE-2 adopted Antiviral antiviral activity applied approach binding pocket binding site caffeine Cell Characteristics chemical property Compound COVID-19 COVID-19 pandemic docking domain dosage drug design effective evaluate function impair Interaction Invasion lack mechanism modeling molecular molecular dynamic simulations Neutral nicotinamide potential mechanism Protein pyridoxamine Safe SARS-CoV-2 selected Side effects Structural analysis Structure the SARS-CoV-2 the Spike thiamin Toxicity Vitamin Vitamin B. [DOI] 10.1007/s00894-022-05356-9 PMC 바로가기
Randomized, Double-Blind, Placebo-Controlled Trial of a Throat Spray with Selected Lactobacilli in COVID-19 OutpatientsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] acting acute respiratory syndrome added Administered administration Amplicon sequencing analyses Analysis antibody Antiviral antiviral property antiviral strategy applied Bacteria benefit Care chills collected Combined coronavirus coronavirus disease COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients detectable Diagnosis diarrhea double-blind dried blood spot eligible evaluated Fever Health hospital Hospitalization infected with SARS-CoV-2 Lactobacillaceae lactobacilli Microbiome modulation multifactorial nasopharyngeal viral load nose-throat swab online questionnaire Outpatient Pain Patient per-protocol analysis Placebo placebo-controlled trial positive potential mechanism practitioners qPCR quantitative PCR Randomized reduce reducing reported reported symptom respiratory tract infection respiratory viral disease SARS-CoV-2 selected sequence severity significantly spray strain Symptom symptom resolution the patient the placebo group therapy Throat throat spray. Treatment Trial trials upper respiratory tract Vaccines variant Viral diseases viral infection Viral load was performed [DOI] 10.1128/spectrum.01682-22 PMC 바로가기
Why Does the Omicron Variant Largely Spare Olfactory Function? Implications for the Pathogenesis of Anosmia in Coronavirus Disease 2019Article Published on 2022-10-172022-11-16 Journal: The Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome alkaline Anosmia cause Cell coronavirus COVID-19 D614G D614G mutation Efficiency Express expressing host cell hydrophobic less Loss of Smell Mucus Mutation olfactory dysfunction Olfactory epithelium olfactory function omicron Omicron variant penetration potential mechanism Prevalence Prevalence. Receptor binding reduce reduced SARS-CoV-2 Support target cell tissue tropism TMPRSS2 transmembrane serine protease variants [DOI] 10.1093/infdis/jiac113 PMC 바로가기
COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protectionArticle Published on 2022-10-152022-11-15 Journal: Journal of Biomedical Science [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] adverse effects analyzed biological basis booster clinical impact COVID-19 COVID-19 vaccine COVID-19 vaccines death effective Effectiveness immune correlate Immunity knowledge pandemic potential mechanism provided public health reduced regimen researcher risk SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 variant SARS-CoV-2 variants severe adverse events the SARS-CoV-2 virus Vaccine Vaccines Variant. virus with COVID-19 [DOI] 10.1186/s12929-022-00853-8 PMC 바로가기
Comparing the B and T cell-mediated immune responses in patients with type 2 diabetes receiving mRNA or inactivated COVID-19 vaccinesArticle Published on 2022-10-112022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome adverse outcome Alpha Anti-RBD IgG BNT162b2 CD4 CD8 cell-mediated immune response cellular Clinical outcome comparable CoronaVac coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 vaccine COVID-19 vaccines diabete dose Effectiveness evaluated first dose healthy individual humoral immune response IgG antibody immune dysfunction Immunological memory immunological memory response Immunological response inactivated Infection influence initial memory mRNA neutralizing antibody neutralizing capacity of BNT162b2 Part Patient platform potential mechanism protective immunity RBD receiving Receptor binding domain reduction in resulting SARS-CoV2 second dose sera susceptibility T cell response T cells T2D Th1 titre Type type 2 diabete type 2 diabetes type 2 diabetes. vaccination vaccinee Vaccines [DOI] 10.3389/fimmu.2022.1018393 PMC 바로가기
In silico evaluation of Philippine Natural Products against SARS-CoV-2 Main ProteaseArticle Published on 2022-10-072022-11-15 Journal: Journal of molecular modeling [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] Activation acute respiratory syndrome ADME ADMET antiviral drug betweenness Betweenness centrality binding site catalytic dyad Clinical treatment complex coronavirus COVID-19 database docking experiments drugs enzyme highest in silico In silico methods in vitro in vivo inhibitor inhibitory inhibitory effect Ligand molecular docking molecular dynamics MPro mutated variant natural natural products network network analysis offer pandemic Population potential mechanism predicted product protease Protein reported residue responsible risk SARS-CoV-2 SARS-CoV-2. severe COVID-19 Spread the SARS-CoV-2 trajectory Vaccine Vaccines viral replication WHO World Health Organization [DOI] 10.1007/s00894-022-05334-1 PMC 바로가기
Exploring the role of Xingren on COVID-19 based on network pharmacology and molecular dockingArticle Published on 2022-10-012022-11-16 Journal: Journal of food biochemistry [Category] 유전자 메커니즘, [키워드] Almond Analysis Anxiety Asthma binding energy blood lipids blood pressure Brain China Chinese cough COVID-19 disease disorder docking drugs enrichment analysis function human immunity IL-17 ingredient intervene involved KEGG pathway mechanism metabolic process molecular molecular docking network network pharmacology Network pharmacology. nine outbreak potential mechanism provide PTGS2 reactive oxygen specy Regulation Research signaling pathway target Treatment variety were used Xingren [DOI] 10.1111/jfbc.14363 PMC 바로가기
Hemolytic anemia in COVID-19코로나19의 용혈성 빈혈Review Published on 2022-09-012022-09-11 Journal: Annals of Hematology [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 Anemia angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 vaccination auto-Abs autoantibodies autoantibody Autoimmune autoimmune hemolytic anemia caused CD147 Complication comprehensive view contributing to COVID-19 COVID-19 patients COVID-19 treatment cytopathic Early detection early diagnosis erythrocyte global pandemic hemolytic hemolytic anemia highlight increasingly Infection Injury Interaction management Medicine Medicines occur offer outcome point-of-care potential mechanism potential mechanisms Prevent prognostic Protein receptor required SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2. Severe acute respiratory syndrome the SARS-CoV-2 Treatment triggered with COVID-19 [DOI] 10.1007/s00277-022-04907-7 PMC 바로가기 [Article Type] Review
Obesity, Hypovitaminosis D, and COVID-19: the Bermuda Triangle in Public Health비만, 비타민 D 부족 및 COVID-19: 공중 보건의 버뮤다 삼각지대Review Published on 2022-09-012022-09-11 Journal: Current obesity reports [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory distress syndrome association body mass body mass index convergence COVID-19 COVID-19 pandemic COVID-19 susceptibility death Evidence explain Genetic genetic data genetic evidence Genome-wide association studies Genome-wide association study higher risk highlighting Hospitalization hypovitaminosis Hypovitaminosis D independent risk factor Infectious complications measure morbidity and mortality obesity outcomes pandemic Pandemics potential mechanism potential mechanisms Prevalence prevalent Public public health recent required respiratory distress risk risk factor robust SARS-CoV-2 SARS-COV-2 infection severe disease severity Severity of disease shown subject suggested syndrome therapeutic Treatment treatment of COVID-19 Triangle Vitamin D vitamin D level vitamin D levels Vitamin D supplementation vitamin D. [DOI] 10.1007/s13679-022-00471-3 PMC 바로가기 [Article Type] Review
Honghua extract mediated potent inhibition of COVID-19 host cell pathways홍화 추출물 매개 코로나19 숙주 세포 경로의 강력한 억제Article Published on 2022-08-222022-09-11 Journal: Scientific Reports [Category] 치료기술, 치료법, 치료제, [키워드] alkaline phosphatase Analysis Antiviral effect applied Chinese Compound COVID-19 crocin enzyme exhibited Extract high affinity host cell human ACE2 receptor Inflammation investigated kinases mechanism Medicine network pharmacology pathway Pathway analysis phosphatase potential mechanism potential mechanisms Signaling signaling pathway Simulation Traditional Traditional Chinese medicine virus [DOI] 10.1038/s41598-022-15338-9 PMC 바로가기 [Article Type] Article